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This Video clearly breaks down the Citric Cycle. The TCA Cycle occurs in the mitochondria. 1 The 2C Acetyl CoA binds with the 4C oxaloacetate to form the 6C citrate. 2 Isomerization of Citrate to isocitrate. 3 Oxidation of isocitrate to alpha ketoglutarate. 4 Oxidation of alpha ketoglutarate to succinyl CoA. 5 Conversion of succinyl CoA to succinate. 6 Oxidation of succinate to fumarate. 7 Hydration of fumerate to malate.